Sodium Hydroxide → 3-(2-{[(Tert-butoxy)carbonyl]amino}acetamido)propanoic acid

HRID 720935

反応式

HRID 720935 の反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 21893946Ethyl 3-(2-{(tert-butoxycarbonyl)amino}acetylamino)propionate

生成物 1

HCID 218938843-(2-{[(Tert-butoxy)carbonyl]amino}acetamido)propanoic acid収率 16%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of (6) at 0° C. (3.43 g; 0.012 mmol) in methanol (40 ml) was treated with 2N sodium hydroxide (6.9 ml; 0.013 mmol). The mixture was stirred at ambient temperature for 90 minutes. After evaporation of the methanol and removal of the insoluble material by filtration, the solution was adjusted to pH5 with 6N hydrochloric acid. The mixture was extracted with dichloromethane and the organic layer evaporated to dryness to give 3-[(2-tertbutoxycarbonylaminoacetyl)amino]propanoic acid (7).

後処理

  1. customAfter evaporation of the methanol and removal of the insoluble material
  2. filtrationby filtration
  3. extractionThe mixture was extracted with dichloromethane
  4. customthe organic layer evaporated to dryness

出典と根拠

ORDレコード
ord-47c9c7199684463cb7fc161e44a736b1
出典データセット
uspto-grants-2006_11
特許番号
US07135502B1

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