3-(4-Methyl-1-piperazine)propan-1-ol → n-[(5s)-3-(3-(4-Methylpiperazin-1-yl)propoxy)-9,10,11-trimethoxy-6,7-dihydro-5h-dibenzo[a,c]cyclohepten-5-yl]acetamide

HRID 720939

反応式

HRID 720939 の反応式
[CH3:1][C:2]([NH:4][CH:5]1[C:15]2[CH:16]=[C:17]([OH:20])[CH:18]=[CH:19][C:14]=2[C:13]2[C:8](=[CH:9][C:10]([O:25][CH3:26])=[C:11]([O:23][CH3:24])[C:12]=2[O:21][CH3:22])[CH2:7][CH2:6]1)=[O:3].O[CH2:28][CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]1>>[CH3:37][N:34]1[CH2:35][CH2:36][N:31]([CH2:30][CH2:29][CH2:28][O:20][C:17]2[CH:18]=[CH:19][C:14]3[C:13]4[C:12]([O:21][CH3:22])=[C:11]([O:23][CH3:24])[C:10]([O:25][CH3:26])=[CH:9][C:8]=4[CH2:7][CH2:6][C@H:5]([NH:4][C:2](=[O:3])[CH3:1])[C:15]=3[CH:16]=2)[CH2:32][CH2:33]1

参加物

3

反応物 2

HCID 792083-(4-Methyl-1-piperazine)propan-1-olHCID 97865N-Acetylcolchicinol

生成物 1

HCID 9848717n-[(5s)-3-(3-(4-Methylpiperazin-1-yl)propoxy)-9,10,11-trimethoxy-6,7-dihydro-5h-dibenzo[a,c]cyclohepten-5-yl]acetamide収率 22%

実験手順

Using an analogous procedure to that described for Example 7, N-acetyl-colchicinol was reacted with 4-(3-hydroxypropyl)-1-methylpiperazine to give N-[(5S)-3-(3-(4-methylpiperazin-1-yl)propoxy)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide.

出典と根拠

ORDレコード
ord-6dd86504269c4126a9a6f0039fa5a4eb
出典データセット
uspto-grants-2006_11
特許番号
US07135502B1

関連ノート

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