Methanol → Methyl 12-aminododecanoate--hydrogen chloride (1/1)

HRID 72097

反応式

HRID 72097 の反応式
O=S(Cl)[Cl:3].[NH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].[CH3:20]O>>[ClH:3].[CH3:20][O:18][C:17](=[O:19])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][NH2:5]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 6966112-Aminododecanoic Acid

生成物 1

HCID 19372000Methyl 12-aminododecanoate--hydrogen chloride (1/1)収率 60%

実験手順

MeOH (40 ml) was cooled to 0-5° C., and SOCl2 (4 ml) was added drop wise with stirring during 30 minutes. 12-Aminododecanoic acid (3 g, 13.9 mmol) was added and the resulting suspension was stirred at 0-5° C. while the ice in cooling bath melted and allowed to warm to room temperature during 16 hours. The mixture was filtered and the solid was dried by suction to afford 2.23 g (60%) of 12-aminododecanoic acid methyl ester hydrochloride. From the mother liquor a further batch of 0.92 g (25%) was isolated.

後処理

  1. temperaturein cooling bath
  2. filtrationThe mixture was filtered
  3. customthe solid was dried by suction

出典と根拠

ORDレコード
ord-e32181550fca4c63a91217fa119ba77b
出典データセット
uspto-grants-2014_09
特許番号
US08828923B2

関連ノート

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