Hydrochloric Acid → HCID 178487951、化合物

HRID 72110ノート

反応式

HRID 72110 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8](O)[C:7]([OH:14])=[N:6]2.O=S(Cl)[Cl:17].Cl>CN(C=O)C>[Cl:17][C:8]1[C:7]([OH:14])=[N:6][C:5]2[C:10]([N:9]=1)=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 178488026HCID 178488026、化合物

生成物 1

HCID 178487951HCID 178487951、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
110 °C

実験手順

A solution (1.53M) of the product of step 1 in DMF was treated with SOCl2 (1 eq) and heated at 110° C. After 1.5 hours, the reaction mixture was cooled and poured into aqueous HCl (1 N). The resulting precipitate was filtered and washed with H2O and Et2O. The dried solid contained predominantly the title compound as a mixture with 6-methoxyquinoxaline-2,3-diol and 2,3-dichloro-6-methoxyquinoxaline. This material was used directly in the subsequent step. MS (ES+) m/z 211 (M+H)+

後処理

  1. temperaturethe reaction mixture was cooled
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with H2O and Et2O

出典と根拠

ORDレコード
ord-46399fd1ef554210ba561c81975c26b7
出典データセット
uspto-grants-2014_09
特許番号
US08828930B2

反応ノート

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