1,1-Dimethylethyl N-[3-methyl-1-(phenylmethyl)-3-pyrrolidinyl]carbamate → tert-butyl N-(3-methylpyrrolidin-3-yl)carbamate

HRID 72118ノート

反応式

HRID 72118 の反応式
C([N:8]1[CH2:12][CH2:11][C:10]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:13])[CH2:9]1)C1C=CC=CC=1>CCO.[Pd]>[CH3:13][C:10]1([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:11][CH2:12][NH:8][CH2:9]1

参加物

4

反応物 1

HCID 104937341,1-Dimethylethyl N-[3-methyl-1-(phenylmethyl)-3-pyrrolidinyl]carbamate

生成物 1

HCID 10798104tert-butyl N-(3-methylpyrrolidin-3-yl)carbamate収率 73.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of tert-butyl 1-benzyl-3-methylpyrrolidin-3-ylcarbamate (1.17 g, 4.0 mmol) in EtOH (40 mL) was added to 10% Pd on C and shaken under 45 psi of H2 for 3 h. The mixture was filtered through Celite and concentrated to afford tert-butyl 3-methylpyrrolidin-3-ylcarbamate (0.59 g, 73%). LC-MS Method 1 tR=0.72 min, m/z=201.

後処理

  1. filtrationThe mixture was filtered through Celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-a10bbe61686241568c560e6b32da5f07
出典データセット
uspto-grants-2014_09
特許番号
US08828985B2

反応ノート

読み込み中…