3,4-Diaminobenzonitrile → 2-Hydroxyquinoxaline-6-carbonitrile

HRID 72124

反応式

HRID 72124 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[NH2:10])[C:5]#[N:6].O.[C:12](O)(=O)[CH:13]=[O:14]>Cl>[O:14]=[C:13]1[CH:12]=[N:1][C:2]2[C:9](=[CH:8][CH:7]=[C:4]([C:5]#[N:6])[CH:3]=2)[NH:10]1

参加物

4

反応物 2

HCID 7372853,4-DiaminobenzonitrileHCID 15620607Glyoxylic acid, monohydrate

生成物 1

HCID 451217302-Hydroxyquinoxaline-6-carbonitrile

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

To a stirred solution of 3,4-diaminobenzonitrile (5.00 g, 37.6 mmol) in 5% aq HCl (20 mL) was added glyoxilic acid monohydrate (4.32 g, 46.9 mmol). The mixture was stirred overnight at rt and filtered. The filter cake was washed with water and MeOH to afford 2-oxo-1,2-dihydroquinoxaline-6-carbonitrile as a grey solid which was used directly in the next step.

後処理

  1. filtrationfiltered
  2. washThe filter cake was washed with water and MeOH

出典と根拠

ORDレコード
ord-f4d6d8765b134ec98904a66135422cd8
出典データセット
uspto-grants-2014_09
特許番号
US08828985B2

関連ノート

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