Potassium Iodide → 1-(6-Chlorobenzotriazol-1-yl)-propan-2-one

HRID 7216

反応式

HRID 7216 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]2[NH:6][N:7]=[N:8][C:4]=2[CH:3]=1.Cl[CH2:12][C:13](=[O:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]([CH2:12][C:13](=[O:15])[CH3:14])[N:7]=[N:8][C:4]=2[CH:3]=1.[Cl:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[N:7][N:8]([CH2:12][C:13](=[O:15])[CH3:14])[C:4]=2[CH:3]=1

参加物

7

反応物 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 178418767HCID 178418767、化合物

生成物 2

HCID 220202521-(6-Chlorobenzotriazol-1-yl)-propan-2-oneHCID 220202531-(5-Chlorobenzotriazol-1-yl)-propan-2-one

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 5 g of 5-chlorobenzotriazole, 1.4 g of chloroacetone, 5.1 g of potassium carbonate and 0.5 g of potassium iodide is stirred into 50 ml of acetone at room temperature for 48 h. The mixture is subsequently filtered, the filtrate concentrated by evaporation in a vacuum, and the residue purified by flash chromatography. In this way, two isomeric products, 1-(5-chlorobenzotriazol-1-yl)-propan-2-one and 1-(6-chlorobenzotriazol-1-yl)-propan-2-one, are isolated in approximately the same quantities, the first of which is then used directly in the next step.

後処理

  1. filtrationThe mixture is subsequently filtered
  2. concentrationthe filtrate concentrated by evaporation in a vacuum
  3. customthe residue purified by flash chromatography

出典と根拠

ORDレコード
ord-1afeb603539e4cb68b366cc59118d27f
出典データセット
uspto-grants-2006_08
特許番号
US07084280B2

関連ノート

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