Dimethylformamide → 4-Butoxy-1-methyl-2-nitrobenzene
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12](Br)[CH2:13][CH2:14][CH3:15].C(=O)([O-])[O-].[Na+].[Na+].CN(C=O)C>CC(OC)(C)C>[CH2:12]([O:8][C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)[CH2:13][CH2:14][CH3:15]参加物
6
反応条件
- 温度
- 80 °C
実験手順
A mixture of 4-methyl-3-nitrophenol (10.0 g), butyl bromide (9.4 g), sodium carbonate (6.9 g) and DMF (50 mL) was heated at 80° C. for 7 hours. The cooled reaction solution was diluted with MTBE and washed twice each with water and sodium hydroxide solution. The organic phase was dried and concentrated. The product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way; MS (ESI): 210 (M+H+).
後処理
- customThe cooled reaction solution
- washwashed twice each with water and sodium hydroxide solution
- customThe organic phase was dried
- concentrationconcentrated
- customThe product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way
出典と根拠
- ORDレコード
- ord-b54f415575cc437c907cf99427af312b
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08828991B2
反応ノート
読み込み中…