Dimethylformamide → 4-Butoxy-1-methyl-2-nitrobenzene

HRID 72196

反応式

HRID 72196 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12](Br)[CH2:13][CH2:14][CH3:15].C(=O)([O-])[O-].[Na+].[Na+].CN(C=O)C>CC(OC)(C)C>[CH2:12]([O:8][C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)[CH2:13][CH2:14][CH3:15]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 8002Butyl bromideHCID 10340Sodium CarbonateHCID 162713-Nitro-p-cresol

生成物 1

HCID 689772014-Butoxy-1-methyl-2-nitrobenzene

試薬・触媒・溶媒 1

HCID 15413tert-Butyl methyl ether溶媒

反応条件

温度
80 °C

実験手順

A mixture of 4-methyl-3-nitrophenol (10.0 g), butyl bromide (9.4 g), sodium carbonate (6.9 g) and DMF (50 mL) was heated at 80° C. for 7 hours. The cooled reaction solution was diluted with MTBE and washed twice each with water and sodium hydroxide solution. The organic phase was dried and concentrated. The product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way; MS (ESI): 210 (M+H+).

後処理

  1. customThe cooled reaction solution
  2. washwashed twice each with water and sodium hydroxide solution
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. customThe product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way

出典と根拠

ORDレコード
ord-b54f415575cc437c907cf99427af312b
出典データセット
uspto-grants-2014_09
特許番号
US08828991B2

関連ノート

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