2-Fluoro-4,5-dimethoxybenzaldehyde → (2-Fluoro-4,5-dimethoxyphenyl)methanol

HRID 722095

反応式

HRID 722095 の反応式
[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>CO>[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:3]=1[CH2:4][OH:5]

参加物

4

反応物 2

HCID 6035952-Fluoro-4,5-dimethoxybenzaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 604215(2-Fluoro-4,5-dimethoxyphenyl)methanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 2-fluoro-4,5-dimethoxy-benzaldehyde (6.0 mmol) in MeOH (10 mL) was treated with NaBH4 (1.2 equiv.) at 0–23° C. for 0.5 h. After quenching with acetone and evaporating the solvent, work-up (CH2Cl2), drying (MgSO4) and evaporation gave the title compound as a crude oily product (94% yield). 1H-NMR (CDCl3): δ 6.90–6.88 (d, 1H), 6.61–6.64 (d, 1H), 4.65–4.63 (d, 2H), 3.86 (s, 3H), 3.84 (s, 3H), 2.00–1.94 (t, 1H).

後処理

  1. customAfter quenching with acetone
  2. customevaporating the solvent, work-up (CH2Cl2)
  3. customdrying
  4. custom(MgSO4) and evaporation

出典と根拠

ORDレコード
ord-ba5a6f0e06aa402396797bbda25049d4
出典データセット
uspto-grants-2006_11
特許番号
US07138401B2

関連ノート

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