Hydroxyamine hydrochloride → HCID 86591374、化合物

HRID 722137ノート

反応式

HRID 722137 の反応式
[Br-].[F:2][C:3]1[C:4]2[CH2:5][CH:6]3[C:15](=[N+:16]4CCCC4)[CH:9]([CH2:10][C:11]=2[CH:12]=[CH:13][CH:14]=1)[CH2:8][CH2:7]3.Cl.NO.O.O.O.C([O-])(=[O:29])C.[Na+].C(O)C.O>O>[F:2][C:3]1[C:4]2[CH2:5][CH:6]3[C:15](=[N:16][OH:29])[CH:9]([CH2:10][C:11]=2[CH:12]=[CH:13][CH:14]=1)[CH2:8][CH2:7]3

参加物

6

反応物 4

HCID 443297Hydroxyamine hydrochlorideHCID 19096565Water ethanolHCID 21882826HCID 21882826、化合物HCID 23665404Sodium Acetate Trihydrate

生成物 1

HCID 86591374HCID 86591374、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The product from Step 2 (1.02 g, 3.02 mmol), hydroxylamine hydrochloride (624 mg, 9.05 mmol) and sodium acetate trihydrate (1.23 g, 9.05 mmol) in 2:1 ethanol-water (12 ml) were heated to reflux and allowed to cool to room temperature, then stirred for 18 hours at this temperature. Water (10 ml) was added and the mixture filtered. The white solid was washed with water and dried under vacuum. 590 mg (89%). m/z 220 (M+H+).

後処理

  1. temperatureto reflux
  2. filtrationthe mixture filtered
  3. washThe white solid was washed with water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-1b8657041d6a4dd0be665e472c1fa7d6
出典データセット
uspto-grants-2006_11
特許番号
US07138400B2

反応ノート

読み込み中…