Thionyl Chloride → 3-Quinuclidinecarbonyl chloride Hydrochloride

HRID 722169

反応式

HRID 722169 の反応式
[ClH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[CH:4]([C:10]([OH:12])=O)[CH2:3]2.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[ClH:15].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[CH:4]([C:10]([Cl:1])=[O:12])[CH2:3]2

参加物

4

反応物 2

HCID 24386Thionyl Chloride2 回HCID 126734361-Azabicyclo(2.2.2)octane-3-carboxylic acid hydrochloride

生成物 1

HCID 126734373-Quinuclidinecarbonyl chloride Hydrochloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

500 mg (2.61 mmol) of 3-quinuclidinecarboxylic acid hydrochloride (Orlek et al., J. Med. Chem. 1991, 34, 2726) are boiled together with 1.9 ml (26.09 mmol) of thionyl choride under reflux for 2 h. The reaction mixture is freed of thionyl chloride under reduced pressure. 20 ml portions of toluene are twice added and evaporated to dryness. The product obtained in this way is reacted further without further purification.

後処理

  1. temperatureunder reflux for 2 h
  2. customevaporated to dryness
  3. customThe product obtained in this way
  4. customis reacted further without further purification

出典と根拠

ORDレコード
ord-da64b4506e7f45239d54214f6ee18580
出典データセット
uspto-grants-2006_11
特許番号
US07138410B2

関連ノート

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