Benzoyl isocyanate, 2-chloro-4-fluoro- → HCID 178488185、化合物

HRID 722201ノート

反応式

HRID 722201 の反応式
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[CH3:14][O:15][C:16]1[CH:21]=[C:20]([C:22]2[NH:26][C:25]([CH3:27])=[N:24][N:23]=2)[CH:19]=[CH:18][C:17]=1[NH2:28]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:28][C:17]1[CH:18]=[CH:19][C:20]([C:22]2[NH:26][C:25]([CH3:27])=[N:24][N:23]=2)=[CH:21][C:16]=1[O:15][CH3:14])=[O:8])=[O:5]

参加物

4

反応物 2

HCID 11521269Benzoyl isocyanate, 2-chloro-4-fluoro-HCID 178488184HCID 178488184、化合物

生成物 1

HCID 178488185HCID 178488185、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The solution of equivalent amounts of 2-chloro-4-fluorobenzoyl isocyanate was added dropwise to the solution of 35 mg of 2-methoxy-4-(5-methyl-4H-[1,2,4]triazol-3-yl)phenylamine in 3 ml of acetonitrile and the mixture was stirred at room temperature for 30 minutes. The solid was then filtered off with suction, stirred with t-butyl methyl ether, filtered off with suction and dried under reduced pressure.

後処理

  1. filtrationThe solid was then filtered off with suction
  2. stirringstirred with t-butyl methyl ether
  3. filtrationfiltered off with suction
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-4144f6acc56a4529a02386356894212a
出典データセット
uspto-grants-2006_11
特許番号
US07138414B2

反応ノート

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