Benzoyl isocyanate, 2-chloro-4-fluoro- → 1-(2-Chloro-4-fluorobenzoyl)-3-[2-methyl-4-(3-methyl-5-oxo-2,5-dihydropyrazol-1-yl)phenyl]urea
反応式
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[C:25](=[O:26])[CH:24]=[C:23]([CH3:27])[NH:22]2)=[CH:17][C:16]=1[CH3:28]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[C:25](=[O:26])[CH:24]=[C:23]([CH3:27])[NH:22]2)=[CH:17][C:16]=1[CH3:28])=[O:8])=[O:5]参加物
4
実験手順
The solution of equivalent amounts of 2-chloro-4-fluorobenzoyl isocyanate in acetonitrile was added dropwise to the solution of 71 mg of 2-(4-amino-3-methylphenyl)-5-methyl-1,2-dihydropyrazol-3-one in 6 ml of acetonitrile and the mixture was stirred at room temperature overnight. The solid formed was filtered off with suction and dried under reduced pressure.