Water → HCID 69439418、化合物

HRID 722238ノート

反応式

HRID 722238 の反応式
[Cl:1][C:2]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:3]=1[C:4]([NH:6][C:7](=[O:25])[NH:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:21][CH2:20][CH:19]([C:22]([OH:24])=[O:23])[CH2:18][CH2:17]1)=[O:5].[OH-].[Na+:33].O>C(O)(C)C>[Na+:33].[Cl:1][C:2]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:3]=1[C:4]([NH:6][C:7](=[O:25])[NH:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:17][CH2:18][CH:19]([C:22]([O-:24])=[O:23])[CH2:20][CH2:21]1)=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 12148754AVE2865

生成物 1

HCID 69439418HCID 69439418、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

The solution of 100 mg of 1-{2-[3-(2-chloro-4,5-difluorobenzoyl)ureido]-4-fluoro-phenyl}piperidine-4-carboxylic acid in 8 ml of isopropanol at 60° C. is admixed with the equimolar amount of 2N sodium hydroxide solution and, after the addition of 20 ml of water, cooled slowly with stirring. The precipitated product is filtered off with suction, washed with isopropanol and water and dried under reduced pressure.

後処理

  1. customat 60° C.
  2. temperaturecooled slowly
  3. filtrationThe precipitated product is filtered off with suction
  4. washwashed with isopropanol and water
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-3b5c905885d243f981e23f7008678800
出典データセット
uspto-grants-2006_11
特許番号
US07138414B2

反応ノート

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