1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 11348948、化合物
反応式
CCN=C=NCCCN(C)C.[NH2:12][C:13]1[S:14][C:15]([CH3:21])=[C:16]([CH3:20])[C:17]=1[C:18]#[N:19].[C:22]1([CH:28]([CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:29](O)=[O:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:18]([C:17]1[C:16]([CH3:20])=[C:15]([CH3:21])[S:14][C:13]=1[NH:12][C:29](=[O:30])[CH:28]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)#[N:19]参加物
4
実験手順
EDCI (61 mg; 0.32 mmol) was added to a solution of 2-Amino-3-cyano-4,5-dimethylthiophene (prepared in Example 1, Step 1; 24 mg; 0.148 mmol) and 2,3-diphenylpropionic acid (72 mg; 0.32 mmol). After stirring for 19 h, the reaction mixture was applied directly to a silica gel column (Merck Silica gel 60, 230–400 mesh, eluent: 10%–33% ethylacetate/hexanes) to provide N-(3-Cyano-4,5-dimethyl-thiophen-2-yl)-2,3-diphenyl-propionamas a white solid (17.0 mg; 39%).