Trifluoroacetic acid → 4-(3-Bromo-5-hydroxy-benzenesulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester

HRID 723039ノート

反応式

HRID 723039 の反応式
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]([C:12]1[S:13][C:14]([S:32][CH3:33])=[C:15]([S:17]([C:20]2[CH:25]=[C:24]([O:26]C(C)(C)C)[CH:23]=[C:22]([Br:31])[CH:21]=2)(=[O:19])=[O:18])[CH:16]=1)=[O:11]>C(Cl)Cl>[CH3:8][O:9][C:10]([C:12]1[S:13][C:14]([S:32][CH3:33])=[C:15]([S:17]([C:20]2[CH:25]=[C:24]([OH:26])[CH:23]=[C:22]([Br:31])[CH:21]=2)(=[O:18])=[O:19])[CH:16]=1)=[O:11]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 210571734-(3-Bromo-5-tert-butoxy-benzenesulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester

生成物 1

HCID 210571774-(3-Bromo-5-hydroxy-benzenesulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester収率 101.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (5 mL) was added to a solution of 4-(3-bromo-5-tert-butoxy-benzenesulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester ((Example 12: step c) 240 mg, 0.5 mmol) in DCM (5 mL). The solution was stirred at rt for 2 h and the solvents were removed in vacuo, yielding 214 mg of an oil (quantitative) which was used without further purification.

後処理

  1. customthe solvents were removed in vacuo

出典と根拠

ORDレコード
ord-6ebd5006aca3447fbcbb52edd4fcc5e8
出典データセット
uspto-grants-2006_11
特許番号
US07138530B2

反応ノート

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