Methyl propionate → 3-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester

HRID 72316

反応式

HRID 72316 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2OC(=O)[S:17][N:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]([O:25][CH3:26])(=[O:24])[CH2:22][CH3:23]>ClC1C=CC=CC=1>[CH3:26][O:25][C:21]([C:22]1[S:17][N:16]=[C:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:14][CH:13]=2)[CH:23]=1)=[O:24]

参加物

4

反応物 2

HCID 11124Methyl propionateHCID 595495255-(4-Benzyloxyphenyl)-[1,3,4]oxathiazol-2-one

生成物 1

HCID 666177513-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

実験手順

5-(4-benzyloxy-phenyl)-[1,3,4]oxathiazol-2-one (0.4 g, 1.4 mmol) and 0.23 ml of methyl propionate were dissolved in 10 ml of chlorobenzene and then refluxed overnight. The solvent was distilled off under reduced pressure and the obtained crude compound was purified by silica gel column chromatography to obtain 3-(4-benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester as a desired compound.

後処理

  1. temperaturerefluxed overnight
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe obtained crude compound
  4. customwas purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-bae299a0dd6140dd87b26a0cdc892800
出典データセット
uspto-grants-2014_09
特許番号
US08828992B2

関連ノート

読み込み中…