Chlorosulfonic acid → 4-Amino-3-bromo-5-nitrobenzenesulfonyl chloride

HRID 723268ノート

反応式

HRID 723268 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11](N)(=[O:13])=[O:12])=[CH:4][C:3]=1[Br:15].[Cl:16]S(O)(=O)=O>>[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11]([Cl:16])(=[O:13])=[O:12])=[CH:4][C:3]=1[Br:15]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 218864374-Amino-3-bromo-5-nitrobenzenesulfonamide

生成物 1

HCID 218861144-Amino-3-bromo-5-nitrobenzenesulfonyl chloride

実験手順

4-Amino-3-bromo-5-nitrobenzenesulfonamide ((U.S. Pat. No. 3,987,199) 1 g, 3.17 mmol) was heated at 95° C. for 3 h in chlorosulfonic acid (10 mL). The solution was cooled then poured onto ice and then filtered. The solid was redissolved in DCM and dried over sodium sulfate. Removal of the solvent yielded the product (960 mg) which was used without further purification.

後処理

  1. temperatureThe solution was cooled
  2. additionthen poured onto ice
  3. filtrationfiltered
  4. dissolutionThe solid was redissolved in DCM
  5. dry with materialdried over sodium sulfate
  6. customRemoval of the solvent

出典と根拠

ORDレコード
ord-d7643db29aef469cab93861f74cd4494
出典データセット
uspto-grants-2006_11
特許番号
US07138530B2

反応ノート

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