Sodium Hydroxide → HCID 69586325、化合物

HRID 723396ノート

反応式

HRID 723396 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][N:7]2[C:10]([CH3:14])=[C:11]([CH3:13])[N:12]=[C:6]2[C:5]=1[NH2:15])(=[O:3])[CH3:2].[S:16]1[CH:20]=[CH:19][C:18]([CH:21]=O)=[CH:17]1.[OH-].[Na+]>C(O)C>[NH2:15][C:5]1[C:6]2[N:7]([C:10]([CH3:14])=[C:11]([CH3:13])[N:12]=2)[CH:8]=[CH:9][C:4]=1[C:1](=[O:3])[CH:2]=[CH:21][C:18]1[CH:19]=[CH:20][S:16][CH:17]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 681353-ThiophenecarboxaldehydeHCID 21873921HCID 21873921、化合物

生成物 1

HCID 69586325HCID 69586325、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 5 g of 7-acetyl-8-amino-2,3-dimethylimidazo[1,2-a]pyridine, 2.9 g of thiophene-3-carboxaldehyde, 1.6 g of sodium hydroxide and 100 ml of ethanol is stirred at room temperature for 3 days. It is then concentrated in vacuo to half the volume, poured onto 100 ml of saturated aqueous ammonium chloride solution and extracted three times with 100 ml of methylene chloride each time. The combined organic phases are washed with a little water, the solvent is stripped off in vacuo and the residue is stirred in ethyl ether. After filtering off and drying in vacuo, 4.6 g of the title compound are obtained.

後処理

  1. concentrationIt is then concentrated in vacuo to half the volume
  2. additionpoured onto 100 ml of saturated aqueous ammonium chloride solution
  3. extractionextracted three times with 100 ml of methylene chloride each time
  4. washThe combined organic phases are washed with a little water
  5. stirringthe residue is stirred in ethyl ether
  6. filtrationAfter filtering off
  7. dry with materialdrying in vacuo, 4.6 g of the title compound
  8. customare obtained

出典と根拠

ORDレコード
ord-f7e60c5bcf7946918cd5500197e33eae
出典データセット
uspto-grants-2006_11
特許番号
US07141567B2

反応ノート

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