Trifluoroacetic acid → (3S,4R)-ethyl 4-(allyloxycarbonyl)piperidine-3-carboxylate
反応式
[CH2:1]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C@H:8]1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:6])[CH:2]=[CH2:3].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][NH:10][CH2:9][C@H:8]1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:6])[CH:2]=[CH2:3]参加物
4
実験手順
A solution of 259B (680 mg, 1.9 mmol) in CH2Cl2 (10 mL) was treated with TFA (1 mL) at room temperature. The reaction mixture was stirred for 16 hours, then concentrated. The residues was dissolved in EtOAc (20 mL) and washed with saturated aqueous NaHCO3 (2×20 mL), dried (Na2SO4), filtered and concentrated in vacuo to afford 170 mg of Compound 259C.
後処理
- concentrationconcentrated
- dissolutionThe residues was dissolved in EtOAc (20 mL)
- washwashed with saturated aqueous NaHCO3 (2×20 mL)
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-bfb5d7df98a74f69a3f8867cfb121a8c
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07141571B2
反応ノート
読み込み中…