4-Toluenesulfonyl chloride → HCID 131725182、化合物

HRID 723642

反応式

HRID 723642 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:12][C:13]1[O:17][C:16]([CH2:18][CH2:19][OH:20])=[CH:15][CH:14]=1>N1C=CC=CC=1>[CH3:12][C:13]1[O:17][C:16]([CH2:18][CH2:19][OH:20])=[CH:15][CH:14]=1.[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O-:10])(=[O:17])=[O:9])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 110623902-(5-Methylfuran-2-yl)ethan-1-ol

生成物 1

HCID 131725182HCID 131725182、化合物収率 152.9%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

4-Methylbenzenesulfonyl chloride (907 mg, 4,76 mmol) was added to a solution of compound 21A (500 mg, 3.96 mmol) in 6 mL of dry pyridine. The reaction was stirred at room temperature for 4 h and then quenched with ice. The reaction mixture was extracted with CH2Cl2 and the combined organic layers were washed with saturated aqueous sodium bicarbonate and water, dried and concentrated under reduced pressure to give 900 mg (81%) of compound 24A as a yellow oil.

後処理

  1. customquenched with ice
  2. extractionThe reaction mixture was extracted with CH2Cl2
  3. washthe combined organic layers were washed with saturated aqueous sodium bicarbonate and water
  4. customdried
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-0d2c06d1412547b89eed8534ad717d46
出典データセット
uspto-grants-2006_11
特許番号
US07141578B2

関連ノート

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