tert-Butyldimethyl(4-nitrophenoxy)silane → 4-((Tert-butyldimethylsilyl)oxy)aniline
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][Si:11]([CH3:17])([CH3:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:6][CH:5]=1)([O-])=O>C(OCC)(=O)C.[Pd]>[CH3:17][Si:11]([CH3:16])([O:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1)[C:12]([CH3:15])([CH3:14])[CH3:13]参加物
4
実験手順
A solution of 1-nitro4-(1,1,2,2-tetramethyl-1-silapropoxy)benzene (7.8 g, 30.8 mmol) (from Example 19a supra) and 10% Pd/C (0.70 g) (Aldrich) in ethyl acetate (100 mL) was hydrogenated for 1 day. The reaction mixture was filtered though Celite® and concentrated. The residue was purified by flash chromatography eluting with ethyl acetate/hexanes (1:9 V/N)) to afford 4-(1,1,2,2-tetramethyl-1-silapropoxy)phenylamine. (Yield 6.7 g, 97%).
後処理
- filtrationThe reaction mixture was filtered though Celite®
- concentrationconcentrated
- customThe residue was purified by flash chromatography
- washeluting with ethyl acetate/hexanes (1:9 V/N))
出典と根拠
- ORDレコード
- ord-a803ccb62a404612ad797f6d240d47bb
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084270B2
反応ノート
読み込み中…