Dimethylformamide → 1,3-Benzothiazole-6-sulfonyl chloride

HRID 723977

反応式

HRID 723977 の反応式
S(Cl)([Cl:3])=O.[S:5]1[C:9]2[CH:10]=[C:11]([S:14]([OH:17])(=O)=[O:15])[CH:12]=[CH:13][C:8]=2[N:7]=[CH:6]1.CN(C)C=O>ClC(Cl)C>[Cl:3][S:14]([C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[CH:6][S:5][C:9]=2[CH:10]=1)(=[O:17])=[O:15]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 143978241,3-Benzothiazole-6-sulfonic acid

生成物 1

HCID 27951701,3-Benzothiazole-6-sulfonyl chloride

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

Thionyl chloride (4 mL) was added to a suspension of the benzothiazole-6-sulfonic acid (0.60 g, 2.79 mmol) in dichloroethane (15 mL) and the reaction mixture was heated at reflux and dimethylformamide (5 mL) was added to the reaction mixture to yield a clear solution. After 1.5 hr. at reflux, the solvent was removed in vacuo and excess HCl and thionyl chloride was chased by evaporation with dichloroethane.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux
  3. customto yield a clear solution
  4. temperatureat reflux
  5. customthe solvent was removed in vacuo and excess HCl and thionyl chloride
  6. customwas chased by evaporation with dichloroethane

出典と根拠

ORDレコード
ord-2f32e40feb3746e2aeafe7f12bdcffe7
出典データセット
uspto-grants-2006_11
特許番号
US07141594B2

関連ノート

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