3-Fluorophenol → 1-Benzhydryl-3-(3-fluorophenoxy)azetidine

HRID 72401

反応式

HRID 72401 の反応式
CS([O:5][CH:6]1[CH2:9][N:8]([CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7]1)(=O)=O.[F:23][C:24]1[CH:25]=[C:26](O)[CH:27]=[CH:28][CH:29]=1>>[CH:10]([N:8]1[CH2:9][CH:6]([O:5][C:28]2[CH:27]=[CH:26][CH:25]=[C:24]([F:23])[CH:29]=2)[CH2:7]1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

3

反応物 2

HCID 97433-FluorophenolHCID 27587161-(Diphenylmethyl)azetidin-3-yl methanesulfonate

生成物 1

HCID 197996211-Benzhydryl-3-(3-fluorophenoxy)azetidine収率 80.9%

実験手順

The title compound (D22) (1.93 g) was prepared according to the experimental procedure described in Description 21 starting from 1-benzhydrylazetidin-3-yl methanesulfonate (D19) (2.5 g, 7.87 mmol) and 3-fluorophenol (0.642 ml, 7.16 mmol).

出典と根拠

ORDレコード
ord-83dabc3e49b94d36991f1f54a4471d05
出典データセット
uspto-grants-2014_09
特許番号
US08828987B2

関連ノート

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