2,4-Difluoroaniline → Tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1-carboxylate

反応式

[C:1]([N:8]1[CH2:11][C:10](=O)[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[F:13][C:14]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:15]=1[NH2:16]>>[F:13][C:14]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:15]=1[NH:16][CH:10]1[CH2:11][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9]1

参加物

反応物 2

HCID 97092,4-Difluoroaniline

HCID 15194043-Oxo-azetidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 63303164Tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1-carboxylate収率 18.1%

実験手順

The title compound (D31) (90 mg) was prepared according to the experimental procedure described in Description 30 starting from 1-Boc-3-azetidinone (300 mg, 1.75 mmol) and 2,4-difluoroaniline (0.178 ml, 1.75 mmol). Reaction time: 1 week.

後処理

customReaction time
custom1 week

出典と根拠

ORDレコード: ord-571fdbfbb6aa41e1b72cc0c12f5d4049
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08828987B2

反応ノート

読み込み中…

参加物