Sodium Hydroxide → 2-(2-Chloro-4-nitrophenyl)acetic acid
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH:11](C(OCC)=O)[C:12]([O:14]CC)=[O:13].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][C:12]([OH:14])=[O:13]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of diethyl 2-(2-chloro-4-nitrophenyl)malonate (step 1, 7.6 g, 24.2 mmol) in methanol (18 ml) was added 6M-NaOH (12 ml) and stirred for 1 h at 50° C. The reaction was quenched by the addition of saturated citric acid aqueous solution (16 ml) and water. The organic layer was extracted with ethyl acetate (2×50 ml), washed with brine, dried (MgSO4) and concentrated to give 4.52 g (87%) of title compound as light yellow solid.
後処理
- customThe reaction was quenched by the addition of saturated citric acid aqueous solution (16 ml) and water
- extractionThe organic layer was extracted with ethyl acetate (2×50 ml)
- washwashed with brine
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-923c42012d42441687435d999549e706
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07141580B2
反応ノート
読み込み中…