Methyl iodide → 3-Methoxythioanisole

HRID 724259

反応式

HRID 724259 の反応式
CI.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([SH:11])[CH:8]=[CH:9][CH:10]=1.[C:12](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][CH3:12])[CH:6]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 849893-Methoxybenzenethiol

生成物 1

HCID 2811823-Methoxythioanisole収率 99.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Methyl iodide (14.67 ml, 0.235 mol) was added dropwise to a solution of 3-methoxy-benzenethiol (30 g, 0.214 mol) and potassium carbonate (29.6 g, 0.214 mol) in acetone (400 ml) under nitrogen at 3° C. The reaction was allowed to warm to room temperature and the solvent was removed under reduced pressure. The residue was diluted with water (300 ml) and the aqueous layer was extracted with diethylether (3×200 ml). The combined organic extracts were dried over MgSO4 and the solvent was removed under reduced pressure to give 1-Methoxy-3-methylsulfanyl-benzene (32.87 g) as a pale yellow liquid.

後処理

  1. customthe solvent was removed under reduced pressure
  2. additionThe residue was diluted with water (300 ml)
  3. extractionthe aqueous layer was extracted with diethylether (3×200 ml)
  4. dry with materialThe combined organic extracts were dried over MgSO4
  5. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-964d102472ee430686ec0e088d7065cf
出典データセット
uspto-grants-2006_11
特許番号
US07141586B2

関連ノート

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