Methyl iodide → 4-(Allyloxy)-2-methoxy-1-(methylsulfanyl)benzene
反応式
[CH2:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([SH:12])=[C:9](O)[CH:10]=1)[CH:2]=[CH2:3].[C:13](=[O:16])([O-])[O-].[K+].[K+].[CH3:19]I>CC(C)=O>[CH2:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([S:12][CH3:19])=[C:9]([O:16][CH3:13])[CH:10]=1)[CH:2]=[CH2:3]参加物
5
実験手順
5-(Allyloxy)-2-sulfanylphenol (37.84 g, 0.21 mol) and potassium carbonate (43 g, 0.31 mol) in acetone (450 ml) was cooled to 5° C. and treated with methyl iodide (32.32 ml, 0.52 mol) dropwise and stirred for 1 h at RT. After removal of the solvent in vacuo, the residue was partioned between diethyl ether (300 ml) and water (400 ml). The aqueous phase was separated and extracted with further diethyl ether (2×150 ml) and the combined organics were dried over MgSO4 and evaporated to a clear oil (26 g, 0.12 mol).
後処理
- customAfter removal of the solvent in vacuo
- customThe aqueous phase was separated
- extractionextracted with further diethyl ether (2×150 ml)
- dry with materialthe combined organics were dried over MgSO4
出典と根拠
- ORDレコード
- ord-4a589f2b4250443392094a9983cb5293
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07141586B2
反応ノート
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