Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate

HRID 72442

反応式

HRID 72442 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:19])[CH2:11][N:10]([C:12](OC(C)(C)C)=O)[CH2:9]2)=[CH:4][CH:3]=1.ClC1[N:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:22]=1[C:23]([O:25][CH3:26])=[O:24]>>[Cl:31][C:28]1[CH:29]=[N:30][C:12]([N:10]2[CH2:9][C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)([OH:19])[CH2:11]2)=[C:22]([CH:27]=1)[C:23]([O:25][CH3:26])=[O:24]

参加物

3

反応物 2

HCID 2764318Methyl 2,5-DichloronicotinateHCID 65813955tert-Butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate

生成物 1

HCID 67958200Methyl 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate収率 60.3%

実験手順

The title compound (D81) (0021/074/1) (75.9 mg) was prepared according to the experimental procedure described in Description 80 starting from tert-butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate (D29) (100 mg, 0.374 mmol) and methyl 2,5-dichloronicotinate (77.32 mg, 0.374 mmol).

出典と根拠

ORDレコード
ord-d3bb85cc8ad3477ba58a356b34090d63
出典データセット
uspto-grants-2014_09
特許番号
US08828987B2

関連ノート

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