Sodium Hydroxide → 6-nitro-1H-indole-2-carboxylic Acid
反応式
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([N+:14]([O-:16])=[O:15])[CH:8]=2)=[O:4].[OH-].[Na+]>CO>[N+:14]([C:9]1[CH:8]=[C:7]2[C:12]([CH:13]=[C:5]([C:3]([OH:4])=[O:2])[NH:6]2)=[CH:11][CH:10]=1)([O-:16])=[O:15]参加物
4
実験手順
4.4 g (20 mmol) 6-Nitro-1H-indole-2-carboxylic acid methyl ester (190) was dissolved in 80 mL methanol and was treated with 30 mL 1M NaOH overnight at 55 C°. The methanol was evaporated, the remaining aqueous solution was diluted to 100 mL and was acidified to pH 2 using concentrated HCl. The precipitate was filtered off, washed three times with water then dried to give 3.92 g (95%) 191 as yellow powder. The NMR was consistent with the structure. 191 was used without further purification.
後処理
- customThe methanol was evaporated
- additionthe remaining aqueous solution was diluted to 100 mL
- filtrationThe precipitate was filtered off
- washwashed three times with water
- customthen dried
出典と根拠
- ORDレコード
- ord-b9e48dbd07354afeaca14050f1d6aff6
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07141680B2
反応ノート
読み込み中…