Water → 5-Azido-3-[3-(trifluoromethoxy)phenyl]-4-thiazolidinone
反応式
[N-:1]=[N+:2]=[N-:3].[Na+].Cl[CH:6]1[S:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]([F:21])([F:20])[F:19])[CH:12]=2)[C:7]1=[O:22].O>CN(C=O)C>[N:1]([CH:6]1[S:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]([F:21])([F:20])[F:19])[CH:12]=2)[C:7]1=[O:22])=[N+:2]=[N-:3]参加物
5
実験手順
Sodium azide (2.78 g) was added to a solution of 5-chloro-3-(3-trifluoromethoxyphenyl)thiazolidin-4-one (7.50 g) in DMF (50 ml). After 2 hours the mixture was poured into water, extracted with ethyl acetate (x3), dried (MgSO4) and concentrated in vacuo to give the sub-title compound (5.40 g), which was used directly in the next step.
後処理
- extractionextracted with ethyl acetate (x3)
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-71eaaef2a35c4368b7ac6d281bce8344
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05705456
反応ノート
読み込み中…