Hydrogen Peroxide → N-(3-trifluoromethyl-phenyl)-4-(2-carbamoyl-4-pyridyl)-2-pyrimidineamine

HRID 724824ノート

反応式

HRID 724824 の反応式
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[N:15]=[C:14]([C:16]3[CH:21]=[CH:20][N:19]=[C:18]([C:22]#[N:23])[CH:17]=3)[CH:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1.OO.C=CCCCC.C(=O)([O-])[O-:35].[Na+].[Na+]>CO>[F:25][C:2]([F:24])([F:1])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[N:15]=[C:14]([C:16]3[CH:21]=[CH:20][N:19]=[C:18]([C:22](=[O:35])[NH2:23])[CH:17]=3)[CH:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1

参加物

6

反応物 4

HCID 784Hydrogen PeroxideHCID 10340Sodium CarbonateHCID 115971-HexeneHCID 19711150N-(3-trifluoromethyl-phenyl)-4-(2-cyano-4-pyridyl)-2-pyrimidineamine

生成物 1

HCID 19711149N-(3-trifluoromethyl-phenyl)-4-(2-carbamoyl-4-pyridyl)-2-pyrimidineamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

100 mg (0.293 mmol) of N-(3-trifluoromethyl-phenyl)-4-(2-cyano-4-pyridyl)-2-pyrimidineamine are suspended in 4 ml of methanol. 1.1 ml of hydrogen peroxide (30%), 0.32 ml of 1-hexene and 22 mg of sodium carbonate are added and the reaction mixture is stirred for 16 hours at RT. The product is isolated by filtration and washed (methanol/water) to give N-(3-trifluoromethyl-phenyl)-4-(2-carbamoyl-4-pyridyl)-2-pyrimidineamine; m.p. 240°-242°, FAB-MS: 360 (M+ +H).

後処理

  1. customThe product is isolated by filtration
  2. washwashed (methanol/water)

出典と根拠

ORDレコード
ord-1267d815aa034903b6b0db6e1dd571d0
出典データセット
uspto-grants-1998_01
特許番号
US05705502

反応ノート

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