化工社化工社 化学情報印刷レポート · 研究参考用
3-(Phenylmethoxy)benzenemethanol → 3-Benzyloxybenzyl bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Phenylmethoxy)benzenemethanol | HCID 74341 | — |
| 反応物 | Bromotrimethylsilane | HCID 76113 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Benzyloxybenzyl bromide | HCID 1502047 | — |
反応手順
A solution of 3-benzyloxybenzyl alcohol (2.04 g) in methylene chloride (20 mL) with TMS Bromide (2.5 eq. 3.14 mL) was heated at reflux for 6 hr. After cooling, the reaction was concentrated and then reconcentrated 2× from methylene chloride. The residue was chromatographed on silica gel with 5% methylene chloride in hexane to afford 3-benzyloxybenzyl bromide (1.26 g) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05705524 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-148bdd1a9f154f59962ee4b9f4440268 |
| 出典メモ | uspto-grants-1998_01 |