戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 72523作成日：2026年10月27日

Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl) pyridin-2-yl)oxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/72523

反応式

関与物質

役割名称HCID仕込み量
反応物Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
反応物5-(Trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acidHCID 86697877—
生成物Methyl 4-(1-(5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl) pyridin-2-yl)oxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoateHCID 8669788168.4%

反応手順

The title compound (D181) (75 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acid (D130) (77 mg, 0.189 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (43.04 mg, 0.189 mmol).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08828987B2
出典データセットuspto-grants-2014_09
ORD IDord-b1cc043b5ca74ef0b57e42026d14aeb7
出典メモuspto-grants-2014_09