HRID72523

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66824369

未命名化合物

结构：O=C(O)c1cc(C(F)(F)F)cnc1N1CC(Oc2cccc(C(F)(F)F)n2)C1

HCID86697877

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(C2(NC(=O)c3cc(C(F)(F)F)cnc3N3CC(Oc4cccc(C(F)(F)F)n4)C3)CC2)cc1

HCID86697881

未命名化合物

收率 68.4%

PROCEDURE

实验过程

The title compound (D181) (75 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acid (D130) (77 mg, 0.189 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (43.04 mg, 0.189 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1cc043b5ca74ef0b57e42026d14aeb7
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08828987B2
来源说明: uspto-grants-2014_09

反应 SMILES

[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[N:5][C:6]([N:12]2[CH2:15][CH:14]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[N:18]=3)[CH2:13]2)=[C:7]([CH:11]=1)[C:8](O)=[O:9].Cl.[NH2:30][C:31]1([C:34]2[CH:43]=[CH:42][C:37]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:35]=2)[CH2:33][CH2:32]1>>[F:28][C:2]([F:1])([F:27])[C:3]1[CH:4]=[N:5][C:6]([N:12]2[CH2:15][CH:14]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:24])([F:25])[F:26])[N:18]=3)[CH2:13]2)=[C:7]([CH:11]=1)[C:8]([NH:30][C:31]1([C:34]2[CH:43]=[CH:42][C:37]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:35]=2)[CH2:33][CH2:32]1)=[O:9]