化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinamido)cyclopropyl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride | HCID 66824369 | — |
| 反応物 | 2-(3-(3-Chlorophenoxy)azetidin-1-yl)-5-fluoronicotinic acid | HCID 67958151 | — |
| 生成物 | Methyl 4-(1-(2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinamido)cyclopropyl)benzoate | HCID 67966658 | 56.3% |
反応手順
The title compound (D188) (12 mg) was prepared according to the experimental procedure described in Description 169 starting from 2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinic acid (D133) (14 mg, 0.043 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (9.85 mg, 0.043 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828987B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c91fa6d648554ee789238ca7d88f7e08 |
| 出典メモ | uspto-grants-2014_09 |