Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinamido)cyclopropyl)benzoate

HRID 72527ノート

反応式

HRID 72527 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10]2[N:18]=[CH:17][C:16]([F:19])=[CH:15][C:11]=2[C:12](O)=[O:13])[CH2:7]1.Cl.[NH2:24][C:25]1([C:28]2[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][CH:29]=2)[CH2:27][CH2:26]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[O:5][CH:6]1[CH2:7][N:8]([C:10]2[N:18]=[CH:17][C:16]([F:19])=[CH:15][C:11]=2[C:12]([NH:24][C:25]2([C:28]3[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][CH:29]=3)[CH2:27][CH2:26]2)=[O:13])[CH2:9]1

参加物

3

反応物 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 679581512-(3-(3-Chlorophenoxy)azetidin-1-yl)-5-fluoronicotinic acid

生成物 1

HCID 67966658Methyl 4-(1-(2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinamido)cyclopropyl)benzoate収率 56.3%

実験手順

The title compound (D188) (12 mg) was prepared according to the experimental procedure described in Description 169 starting from 2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-fluoronicotinic acid (D133) (14 mg, 0.043 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (9.85 mg, 0.043 mmol).

出典と根拠

ORDレコード
ord-c91fa6d648554ee789238ca7d88f7e08
出典データセット
uspto-grants-2014_09
特許番号
US08828987B2

反応ノート

読み込み中…