3-Azabicyclo[3.2.2]nonane → 3-(4-Chloro-1-naphthylsulfonyl)-3-azabicyclo[3.2.2]nonane

反応式

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([S:12](Cl)(=[O:14])=[O:13])=[CH:4][CH:3]=1.[CH:16]12[CH2:24][CH2:23][CH:20]([CH2:21][CH2:22]1)[CH2:19][NH:18][CH2:17]2.CCN(C(C)C)C(C)C>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([S:12]([N:18]2[CH2:19][CH:20]3[CH2:23][CH2:24][CH:16]([CH2:22][CH2:21]3)[CH2:17]2)(=[O:14])=[O:13])=[CH:4][CH:3]=1

参加物

反応物 3

HCID 92403-Azabicyclo[3.2.2]nonane

HCID 81531Diisopropylethylamine

HCID 2538044-chloronaphthalene-1-sulfonyl chloride

生成物 1

HCID 197087063-(4-Chloro-1-naphthylsulfonyl)-3-azabicyclo[3.2.2]nonane

実験手順

The title compound was prepared by reacting 4-chloro-1-naphthalenesulfonyl chloride (0.27 g) with 3-azabicyclo[3.2.2]nonane (0.13 g) in the presence of DIEA using a procedure similar to that used in Example 5. Yield: 0.33 g, mp: 133.9°-137.3° C.

出典と根拠

ORDレコード: ord-aa6833c01b754389878d901d66d96af6
出典データセット: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05707985

反応ノート

読み込み中…