tert-Butoxy bis(dimethylamino)methane → [2-(2-Chloro-6-methoxyquinolin-4-yl)ethenyl]dimethylamine

反応式

[Cl:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.C(O[CH:20](N(C)C)[N:21]([CH3:23])[CH3:22])(C)(C)C>>[Cl:1][C:2]1[CH:11]=[C:10]([CH:12]=[CH:20][N:21]([CH3:23])[CH3:22])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1

参加物

反応物 2

HCID 79885tert-Butoxy bis(dimethylamino)methane

HCID 2247882-Chloro-6-methoxy-4-methylquinoline

生成物 1

HCID 53676043[2-(2-Chloro-6-methoxyquinolin-4-yl)ethenyl]dimethylamine収率 92.6%

反応条件

温度: 120 °C

実験手順

2-Chloro-6-methoxy-4-methylquinoline (25 g, 0.12 mol) and tert-butoxybis(dimethylamino)methane (Bredereck's reagent) (30 g, 0.17 mol) was stirred under heating at 120° C. for 1.5 hours. After cooling the reaction mixture, the precipitated crystals were washed with diisopropyl ether to obtain the title compound (29.2 g, 92%).

後処理

temperatureAfter cooling the reaction mixture
washthe precipitated crystals were washed with diisopropyl ether

出典と根拠

ORDレコード: ord-028b9fadd9ed40c7aa6cd3c86c81a0b0
出典データセット: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05708005

反応ノート

読み込み中…

参加物