N-Methylbutylamine → Acetamide, 2-bromo-N-butyl-N-methyl-
反応式
[Br:1][CH2:2][C:3](Br)=[O:4].[CH2:6]([NH:10][CH3:11])[CH2:7][CH2:8][CH3:9]>CCOCC.O>[Br:1][CH2:2][C:3]([N:10]([CH2:6][CH2:7][CH2:8][CH3:9])[CH3:11])=[O:4]参加物
5
実験手順
To a solution cooled to -20° C. of 11.9 ml of bromoacetyl bromide in 180 ml of ether there were added 26 g of butylmethyl amine in solution in 120 ml of ether and then the temperature returned to 20° C. The mixture was stirred for 30 minutes diluted with water and extracted with ether. The ether phase was evaporated to dryness under reduced pressure and the 27.4 g of residue were distilled under reduced pressure (0.05 mbar) at 79/83° C. to obtain. 19.36 g of the desired product.
後処理
- customreturned to 20° C
- extractionextracted with ether
- customThe ether phase was evaporated to dryness under reduced pressure
- distillationthe 27.4 g of residue were distilled under reduced pressure (0.05 mbar) at 79/83° C.
- customto obtain
出典と根拠
- ORDレコード
- ord-80483b027e8842b2b353a06affbbfef9
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05707982
反応ノート
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