2-Propenoic acid, 3-(2-chloro-4-fluorophenyl)- → 3-(2-chloro-4-fluorophenyl)propanoic acid

HRID 726144

反応式

HRID 726144 の反応式
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[H][H]>C(O)C.O.[Pt]=O>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

参加物

5

反応物 2

HCID 27250652-Propenoic acid, 3-(2-chloro-4-fluorophenyl)-HCID 178418361HCID 178418361、化合物

生成物 1

HCID 117695833-(2-chloro-4-fluorophenyl)propanoic acid収率 101.4%

試薬・触媒・溶媒 2

HCID 86587499Platinum oxide monohydrate触媒HCID 702Ethanol溶媒

実験手順

A mixture of 2-chloro-4-fluorocinnamic acid (22.9 g, 0.11 mol) and platinum oxide hydrate (0.5 g, EM Scientific) in 95% ethanol (140 ml) was placed on a Parr hydrogenation apparatus. After the appropriate amount of hydrogen was taken up, the catalyst was filtered and the mixture was concentrated in vacuo to give 22.6 g (98%) of 3-(2-chloro-4-fluorophenyl)propanoic acid as a purple solid. This material was used without further purification.

後処理

  1. filtrationthe catalyst was filtered
  2. concentrationthe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-42500ebc25824cfa82c7d3a5689ba03c
出典データセット
uspto-grants-1998_01
特許番号
US05708033

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