Sodium Hydroxide → HCID 19710644、化合物
反応式
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[S:13][CH2:12][CH:11]=[CH:10]2)=[O:4].[OH-].[Na+]>C(O)C>[S:13]1[C:14]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[C:3]([OH:4])=[O:2])[CH:10]=[CH:11][CH2:12]1参加物
4
実験手順
Methyl-2H-thiochromene-8-carboxylate (0.300 g, 1.46 mmol) was dissolved in ethanol (5 ml) and treated with 10% sodium hydroxide solution (10 ml). The mixture was then heated to reflux with stirring. After 5 h, the reaction mixture was allowed to cool The ethanol present was then removed by evaporation under reduced pressure. The aqueous residue was then washed with CH2Cl2 (2x) before being acidified to pH1 using 5M HCl. The resultant pale yellow precipitate was then filtered off and dried in vacuo to give the title compound (0.195 g, 69%) as a pale yellow solid.
後処理
- temperatureThe mixture was then heated
- temperatureto reflux
- custompresent was then removed by evaporation under reduced pressure
- washThe aqueous residue was then washed with CH2Cl2 (2x)
- filtrationThe resultant pale yellow precipitate was then filtered off
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-e551cc2ee1c74dc5bf217ae47727ac41
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05708174
反応ノート
読み込み中…