Water → Benzyl 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetate

HRID 726469

反応式

HRID 726469 の反応式
[H-].[Na+].[CH3:3][C:4]1([CH3:20])[CH2:13][CH2:12][C:11]([CH3:15])([CH3:14])[C:10]2[CH:9]=[C:8]([CH2:16][C:17]([OH:19])=[O:18])[CH:7]=[CH:6][C:5]1=2.[CH2:21](Br)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.O>CN(C=O)C>[CH3:3][C:4]1([CH3:20])[CH2:13][CH2:12][C:11]([CH3:14])([CH3:15])[C:10]2[CH:9]=[C:8]([CH2:16][C:17]([O:19][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:18])[CH:7]=[CH:6][C:5]1=2

参加物

6

反応物 4

HCID 962WaterHCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 181779322-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetic acid

生成物 1

HCID 18792286Benzyl 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

730 mg (0.024 mol) of sodium hydride (80 and 100 ml of DMF were introduced into a three-necked flank under a nitrogen stream. A solution of 5 g (0.02 mol) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetic acid in 40 ml of DMF was added dropwise and the mixture was stirred until the gaseous emission ceased. 2.9 ml (0.024 mol) of benzyl bromide were then added and the mixture was stirred at room temperature for 4 hours. The reaction medium was poured into water, and extracted with ethyl acetate. The organic phase was decanted off, dried over magnesium sulfate and evaporated. 6.7 g (100%) of the expected ester were recovered in the form of a slightly yellow oil.

後処理

  1. stirringthe mixture was stirred at room temperature for 4 hours
  2. extractionextracted with ethyl acetate
  3. customThe organic phase was decanted off
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. custom6.7 g (100%) of the expected ester were recovered in the form of a slightly yellow oil

出典と根拠

ORDレコード
ord-ef9d103de7344601a737fc0d84aab076
出典データセット
uspto-grants-1998_01
特許番号
US05709867

関連ノート

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