Methyl 1-methyl-5-nitro-1H-pyrrole-2-carboxylate → Methyl 5-amino-1-methyl-1H-pyrrole-2-carboxylate
反応式
[CH3:1][N:2]1[C:6]([N+:7]([O-])=O)=[CH:5][CH:4]=[C:3]1[C:10]([O:12][CH3:13])=[O:11]>[Pd].CO>[CH3:1][N:2]1[C:6]([NH2:7])=[CH:5][CH:4]=[C:3]1[C:10]([O:12][CH3:13])=[O:11]参加物
4
実験手順
1.31 g (7.4 mmol) of methyl N-methyl-5-nitro-2-pyrrolecarboxylate, 400 mg of palladium on carbon (10%) and 50 ml of methanol were introduced into a reactor. The mixture was hydrogenated at room temperature and at a pressure of 7 bar for 2 hours. The catalyst was filtered, washed twice with 25 ml of methanol and the filtrates evaporated. 1.1 g (100%) of the expected amine was recovered in the form of a dark red oil.
後処理
- filtrationThe catalyst was filtered
- washwashed twice with 25 ml of methanol
- customthe filtrates evaporated
- custom1.1 g (100%) of the expected amine was recovered in the form of a dark red oil
出典と根拠
- ORDレコード
- ord-240b193a74654233bc58222f2f2de360
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05709867
反応ノート
読み込み中…