Sodium borohydride → 5-(Hydroxymethyl)thiophene-2-carbonitrile
反応式
[C:1]([C:3]1[S:4][C:5]([CH:8]=[O:9])=[CH:6][CH:7]=1)#[N:2].[BH4-].[Na+]>CCO>[C:1]([C:3]1[S:4][C:5]([CH2:8][OH:9])=[CH:6][CH:7]=1)#[N:2]参加物
4
実験手順
To a solution of 2-cyano-5-formyl-thiophene (6.9 g, 50 mmol) in EtOH (100 mL) was added sodium borohydride (1.9 g, 50 mmol) in portions. After 5 min of stirring, the solvent was removed in vacuo and the residue was partitioned between ethyl acetate and brine. The layers were separated and the organic phase was washed once with 1M citric acid and once with brine, then dried (MgSO4), filtered and concentrated in vacuo to give 6.1 g (88%) of 2-cyano-5-(hydroxymethyl)thiophene.
後処理
- customthe solvent was removed in vacuo
- customthe residue was partitioned between ethyl acetate and brine
- customThe layers were separated
- washthe organic phase was washed once with 1M citric acid and once with brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-a713b903bc31442288d3b8f3fff8e84a
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05710130
反応ノート
読み込み中…