Piperazine → 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

HRID 72673

反応式

HRID 72673 の反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=1>C1COCC1>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=1

参加物

4

反応物 2

HCID 4837PiperazineHCID 923422-Chloro-5-(trifluoromethyl)pyridine

生成物 1

HCID 6676181-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Piperazine (1.2 g, 13.77 mM) was heated with 2-chloro-5-(trifluoromethyl)pyridine (0.5 g, 2.75 mmol) in THF (2 mL) for 2 hours. Subsequently the reaction mixture was poured onto crushed ice and extracted with ethyl acetate. The organic layer was washed with sodium bicarbonate and evaporated to furnish the required product.

後処理

  1. additionSubsequently the reaction mixture was poured
  2. customonto crushed ice
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with sodium bicarbonate
  5. customevaporated

出典と根拠

ORDレコード
ord-2539442d428d4383a6d9b930dc5daea0
出典データセット
uspto-grants-2014_09
特許番号
US08828999B2

関連ノート

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