Triethylamine → HCID 19707506、化合物

HRID 726748

反応式

HRID 726748 の反応式
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[CH2:10][CH2:11][NH2:12])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:25][O:26][CH2:27][C:28](Cl)=[O:29]>O1CCCC1>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH2:10][CH2:11][NH:12][C:28](=[O:29])[CH2:27][O:26][CH3:25])[CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 96623Methoxyacetyl chlorideHCID 112763943-Cyclopentyloxy-4-methoxyphenethylamine

生成物 1

HCID 19707506HCID 19707506、化合物収率 38.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-cyclopentyloxy-4-methoxyphenethylamine (0.2 g, 0.85 mmol) in tetrahydrofuran (6 mL) was cooled to 0° C. and was treated with triethylamine (0.13 mL, 0.92 mmol) and methoxyacetyl chloride (0.078 mL, 0.85 mmol). The reaction was stirred under an argon atmosphere for 0.25 h, then was partitioned between methylene chloride and water. The extract was dried (potassium carbonate) and evaporated. Purification by flash chromatography, eluting with 5% methanol/chloroform, provided an oil; additional 0.1 g of impure product also obtained).

後処理

  1. customwas partitioned between methylene chloride and water
  2. dry with materialThe extract was dried (potassium carbonate)
  3. customevaporated
  4. customPurification by flash chromatography
  5. washeluting with 5% methanol/chloroform
  6. customprovided an oil

出典と根拠

ORDレコード
ord-91f4cebc236d47f8883b51e796df83af
出典データセット
uspto-grants-1998_01
特許番号
US05710180

関連ノート

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