Piperazine → HCID 18423149、化合物

HRID 72675ノート

反応式

HRID 72675 の反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[C:12]([O:14][CH3:15])[N:11]=[C:10]([O:16][CH3:17])[CH:9]=1>C(#N)C>[CH3:15][O:14][C:12]1[N:11]=[C:10]([O:16][CH3:17])[CH:9]=[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[N:13]=1

参加物

4

反応物 2

HCID 4837PiperazineHCID 806004-Chloro-2,6-dimethoxypyrimidine

生成物 1

HCID 18423149HCID 18423149、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Piperazine (1.23 g, 14.32 mmol) was treated with 6-chloro-2,4-dimethoxy pyrimidine (0.5 g, 2.86 mmol) in acetonitrile (5 mL) and the reaction mixture was stirred at room temperature for 6 hours. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with aqueous sodium bicarbonate solution and evaporated to furnish the required compound.

後処理

  1. additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
  2. extractionextracted with ethyl acetate (25 ml)
  3. washThe organic layer was washed with aqueous sodium bicarbonate solution
  4. customevaporated

出典と根拠

ORDレコード
ord-8af2c11b57d54f988b7d70e12df7b2c8
出典データセット
uspto-grants-2014_09
特許番号
US08828999B2

反応ノート

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