Piperazine → 1-(5-Nitropyridin-2-yl)piperazine
反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>O1CCCC1>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]参加物
4
実験手順
2-Bromo-5-nitropyridine (0.3 g, 1.48 mmol) was treated with piperazine (0.64 g, 7.89 mmol) in tetrahydrofuran (4 ml) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with brine and evaporated to furnish the product.
後処理
- additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
- extractionextracted with ethyl acetate (25 ml)
- washThe organic layer was washed with brine
- customevaporated
- customto furnish the product
出典と根拠
- ORDレコード
- ord-f5dcf78513fb4a359bf8be3f6ed6cc51
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08828999B2
反応ノート
読み込み中…