tert-Butyl (2S)-5-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}pentanoate → (S)-tert-Butyl 5-amino-2-((tert-butoxycarbonyl)amino)pentanoate

HRID 726906

反応式

HRID 726906 の反応式
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:10][CH2:11][CH2:12][NH:13]C(OCC1C=CC=CC=1)=O)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([NH:8][C@H:9]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:10][CH2:11][CH2:12][NH2:13])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 10047875tert-Butyl (2S)-5-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}pentanoate

生成物 1

HCID 7006667(S)-tert-Butyl 5-amino-2-((tert-butoxycarbonyl)amino)pentanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Mix N-t-butyloxycarbonyl-N5 -benzyloxycarbonyl-ornithine, t-butyl ester (2.0 g, 5.0 mmol) and 10% palladium/carbon (0.5 g) in 95% ethanol (40 mL). Hydrogenate at room temperature at atmospheric pressure. Filter and evaporate the filtrate in vacuo to give N-t-butyloxycarbonyl-ornithine, t-butyl ester.

後処理

  1. customat room temperature
  2. filtrationFilter
  3. customevaporate the filtrate in vacuo

出典と根拠

ORDレコード
ord-94ac1031f51e40399e2981165d814800
出典データセット
uspto-grants-1998_01
特許番号
US05710324

関連ノート

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